BRCA1, a Potential Predictive Biomarker in the Treatment of Breast Cancer
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CME Activity Information |
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Release Date: |
February 12, 2007 |
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Most Recent Review: |
February 12, 2007* |
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Most Recent Update: |
February 12, 2007 |
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Date Credit Expires: |
February 12, 2009 |
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Time to Complete: |
1 hour |
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Medium: |
Internet Online |
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*Click here
to learn more about our review process. |
Instructions for Participation
- Read the following information before beginning the educational activity
and click the "Take this course" link at the bottom of the page
- Study the educational activity
- Complete the CME quiz and evaluation
- After successful completion of the CME quiz and evaluation, you will receive
the credit or participation certificate
*The CME quiz and evaluation must be completed by February 12, 2009, in
order to receive the credit or participation certificate.
Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine
in breast cancer and are involved in providing patient care in a cancer care environment.
Learning Objectives
After completing this course, the reader should be able to:
- List the biomarkers that are currently used and those that may be of potential
use in the management of breast cancer.
- Explain how BRCA1 is involved in the development of both inherited and sporadic
breast cancer.
- Discuss the potential role of BRCA1 as a determinant of response to different
types of chemotherapy agents.
- Describe the relationship between BRCA1 and basal-like breast cancer.
Accreditation and Credit Designation
This activity has been planned and implemented in accordance
with the Essential Areas and policies of the Accreditation Council for Continuing
Medical Education (ACCME) through the joint sponsorship of the National Institutes
of Health Foundation for Advance Education in the Sciences (NIH/FAES) and The
Oncologist. The NIH/FAES is accredited by the ACCME to provide continuing
medical education for physicians.
The NIH/FAES designates this educational activity for a maximum of 1.00 AMA
PRA Category 1 Credit™. Physicians should only claim credit commensurate
with the extent of their participation in the activity.
Disclosure Policy
In compliance with the Standards of the ACCME, it is the policy of the NIH/FAES to ensure balance,
independence, objectivity, and scientific rigor in all of its educational activities
and to include information free of commercial bias and based on the best evidence
available. All individuals in a position to influence the content of this activity
have disclosed relevant financial interests or relationships of their own, their
spouse/partner, or their worksite, with manufacturers or providers of commercial
products, services, technology, or programs; and disclosed relationships with
current non-governmental supporters of the activity. The faculty and planners
have indicated that they have no relevant commercial relationships. For a list
of the faculty and planners, please visit the Editorial Board online at http://cme.theoncologist.com/misc/edboard.shtml.
All information is submitted and reviewed and found to be scientifically rigorous,
based on the best available evidence, fair and balanced, and free of commercial
bias. All the recommendations involving clinical medicine in this CME activity
are based on evidence that is accepted within the profession of medicine as
adequate justification for their indications and contraindications in the care
of patients. All scientific research referred to, reported or used in CME in
support or justification of a patient care recommendation conforms to the generally
accepted standards of experimental design, data collection and analysis.
Any potential conflicts of interests are resolved via The Oncologist's
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All manuscripts are reviewed by the Editorial Board with ad hoc assistance from
two or more external experts in the field. All final publication decisions are
made by the Editorial Board. The acceptance of a manuscript is based on its
originality and importance to the field as assessed by the Editors.
Author Disclosure(s)
Colin R. James, M.D.
Credentials: Centre for Cancer Research and Cell Biology,
Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom.
Disclosures: The author has indicated no relevant commercial
relationships.
Jennifer E. Quinn, M.Chem., Ph.D.
Credentials: Centre for Cancer Research and Cell Biology,
Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom.
Disclosures: The author has indicated no relevant commercial
relationships.
Paul B. Mullan, B.Sc., Ph.D.
Credentials: Centre for Cancer Research and Cell Biology,
Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom.
Disclosures: The author has indicated no relevant commercial
relationships.
Patrick G. Johnston, M.D., Ph.D.
Credentials: Centre for Cancer Research and Cell Biology,
Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom.
Disclosures: The author has indicated no relevant commercial
relationships.
D. Paul Harkin, B.Sc., Ph.D.
Credentials: Medical Oncology Clinic, Jules Bordet Institute,
Brussels, Belgium. Telephone: (+44)289032 9241; Fax:
(+44)289026 3744; E-mail: d.harkin{at}qub.ac.uk.
Disclosures: The author has indicated no relevant commercial
relationships.
Commercial Support
Non-governmental supporters of this activity: AstraZeneca, Bristol-Myers
Squibb Oncology, and sanofi-aventis
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