Flat-Fixed Dosing Versus Body Surface Area–Based Dosing of Anticancer Drugs in Adults: Does It Make a Difference?
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CME Activity Information |
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Release Date: |
August 31, 2007 |
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Most Recent Review: |
August 31, 2007* |
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Most Recent Update: |
August 31, 2007 |
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Date Credit Expires: |
August 31, 2009 |
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Time to Complete: |
1 hour |
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Medium: |
Internet Online |
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*Click here
to learn more about our review process. |
Instructions for Participation
- Read the following information before beginning the educational activity
and click the "Take this course" link at the bottom of the page
- Study the educational activity
- Complete the CME quiz and evaluation
- After successful completion of the CME quiz and evaluation, you will receive
the credit or participation certificate
*The CME quiz and evaluation must be completed by August 31, 2009, in order
to receive the credit or participation certificate.
Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine
in clinical pharmacology and are involved in providing patient care in a cancer
care environment.
Learning Objectives
After completing this course, the reader should be able to:
- Describe how and why BSA-based dosing was implemented into oncology.
- Discuss if flat-fixed dosing of adults has advantages over BSA-based dosing
in terms of interpatient pharmacokinetic variation of anticancer drugs, efficiency,
and costs.
- Explain which alternative dosing strategies for BSA-based dosing may have
potential, leading to a minimum of adverse events and superior therapeutic
outcome.
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with the Essential Areas and policies of the Accreditation Council for Continuing
Medical Education (ACCME) through the joint sponsorship of the National Institutes
of Health Foundation for Advance Education in the Sciences (NIH/FAES) and The
Oncologist. The NIH/FAES is accredited by the ACCME to provide continuing
medical education for physicians.
The NIH/FAES designates this educational activity for a maximum of 1.00 AMA
PRA Category 1 Credit™. Physicians should only claim credit commensurate
with the extent of their participation in the activity.
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Author Disclosure(s)
Ron H. J. Mathijssen, M.D., Ph.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands. Telephone: 31-10-4391-112; Fax:
31-10-4391-053; E-mail: a.mathijssen{at}erasmusmc.nl.
Disclosures: The author has indicated no relevant commercial
relationships.
Floris A. de Jong, Ph.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Walter J. Loos, Ph.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Jessica M. van der Bol, M.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Jaap Verweij, M.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Alex Sparreboom, M.D.
Credentials: Department of Medical Oncology, Erasmus University
Medical Center Rotterdam – Daniel den Hoed Cancer Center, Rotterdam,
The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Commercial Support
Non-governmental supporters of this activity: AstraZeneca, Bristol-Myers
Squibb Oncology, Pfizer, and sanofi-aventis
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