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Clinical Pharmacology
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2008
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Prolonged Versus Standard Gemcitabine Infusion: Translation of Molecular Pharmacology to New Treatment Strategy
Prolonged Versus Standard Gemcitabine Infusion: Translation of Molecular Pharmacology to New Treatment Strategy
13-3-261_Veltkamp
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CME Activity Information |
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Release Date: |
April 7, 2008 |
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Most Recent Review: |
April 7, 2008* |
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Most Recent Update: |
April 7, 2008 |
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Date Credit Expires: |
April 7, 2010 |
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Time to Complete: |
1 hour |
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Medium: |
Internet Online |
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*Click here
to learn more about our review process. |
Instructions for Participation
- Read the following information before beginning the educational activity
and click the "Take this course" link at the bottom of the page
- Study the educational activity
- Complete the CME quiz and evaluation
- After successful completion of the CME quiz and evaluation, you will receive
the credit or participation certificate
*The CME quiz and evaluation must be completed by April 7, 2010, in order
to receive the credit or participation certificate.
Target Audience
Physicians who wish to advance their current knowledge of clinical cancer medicine
in clincial pharmacology and are involved in providing patient care in a cancer
care environment.
Learning Objectives
After completing this course, the reader should be able to:
- Describe the molecular pharmacology of nucleoside analogues.
- Explain transport, metabolism, and elimination in relation to the activity
of gemcitabine.
- Describe the clinical pharmacology of gemcitabine in relation to its rate
of administration.
Accreditation and Credit Designation
This activity has been planned and implemented in accordance
with the Essential Areas and policies of the Accreditation Council for Continuing
Medical Education (ACCME) through the joint sponsorship of the School of Medicine
of The University of North Carolina at Chapel Hill and The Oncologist.
The School of Medicine of The University of North Carolina at Chapel Hill is accredited
by the ACCME to provide continuing medical education for physicians.
The School of Medicine of The University of North Carolina at Chapel Hill designates
this educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™.
Physicians should only claim credit commensurate with the extent of their participation
in the activity.
Disclosure Policy
In compliance with the ACCME Standards of Commercial Support, it is the policy
of the School of Medicine of The University of North Carolina at Chapel Hill to
ensure balance, independence, objectivity, and scientific rigor in all of its
educational activities and to include information free of commercial bias and
based on the best evidence available. All individuals in a position to influence
the content of this activity have disclosed relevant financial interests or relationships
of their own, their spouse/partner, or their worksite, with manufacturers or providers
of commercial products, services, technology, or programs; and disclosed relationships
with current non-governmental supporters of the activity.
All information is submitted and reviewed and found to be scientifically rigorous,
based on the best available evidence, fair and balanced, and free of commercial
bias. All the recommendations involving clinical medicine in this CME activity
are based on evidence that is accepted within the profession of medicine as
adequate justification for their indications and contraindications in the care
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peer review process
All manuscripts are reviewed by the Editorial Board with ad hoc assistance from
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All final publication decisions are made by the Editorial Board. The acceptance
of a manuscript is based on its originality and importance to the field as assessed
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Content Review
The content of this manuscript has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias.
Author Disclosure(s)
Stephan A. Veltkamp, M.D., Pharm.D.
Credentials: Division of Experimental Therapy and Department
of Clinical Pharmacology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek
Hospital, Amsterdam, The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships.
Jos H. Beijnen, Ph.D., Pharm.D.
Credentials: Department of Pharmacy & Pharmacology,
Slotervaart Hospital, Amsterdam, The Netherlands; Faculty of Science, Department
of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug
Toxicology, Utrecht University, Utrecht, The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships..
Jan H. M. Schellens, M.D., Ph.D.
Credentials: Professor, Division of Experimental Therapy
and Department of Clinical Pharmacology, The Netherlands Cancer Institute/Antoni
van Leeuwenhoek Hospital, Amsterdam, The Netherlands; Faculty of Science,
Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division
of Drug Toxicology, Utrecht University, Utrecht, The Netherlands.
Disclosures: The author has indicated no relevant commercial
relationships..
Section Editor Disclosure
Mace Rothenberg, M.D., F.A.C.P., has disclosed no financial relationships relevant to the content of this article.
CME Activity Director Disclosure
Frank M. Balis, M.D., CME Activity Director, has disclosed no financial relationships relevant to the content of this article.
Independent Peer Reviewers and Staff Managers Disclosures
No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers or staff managers.
Commercial Support
Non-governmental supporters of this activity: Abraxis BioScience,
AstraZeneca, Bristol-Myers Squibb Oncology, Merck, Pfizer, and sanofi-aventis
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