Epidermal Growth Factor Receptor Expression and Mutational Analysis in Synovial Sarcomas and Malignant Peripheral Nerve Sheath Tumors

CME Activity Information
Release Date:	April 30, 2008
Most Recent Review:	April 30, 2008*
Most Recent Update:	April 30, 2008
Date Credit Expires:	April 30, 2010
Time to Complete:	1 hour
Medium:	Internet Online
*Click here to learn more about our review process.

Instructions for Participation

1. Read the following information before beginning the educational activity and click the "Take this course" link at the bottom of the page
2. Study the educational activity
3. Complete the CME quiz and evaluation
4. After successful completion of the CME quiz and evaluation, you will receive the credit or participation certificate

   *The CME quiz and evaluation must be completed by April 30, 2010, in order to receive the credit or participation certificate.

1. Discuss the significance of deletions and mutations of the EGFR gene in cancer cell growth and survival.
2. Describe the significance of the role of EGFR in malignant peripheral nerve sheath tumors, especially those associated with neurofibromatosis 1.
3. Discuss the significance of why small molecule inhibitor therapy has been ineffectual in synovial sarcomas and malignant peripheral nerve sheath tumors.

All information is submitted and reviewed and found to be scientifically rigorous, based on the best available evidence, fair and balanced, and free of commercial bias. All the recommendations involving clinical medicine in this CME activity are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection and analysis.

Any potential conflicts of interests are resolved via The Oncologist's anonymous peer review process All manuscripts are reviewed by the Editorial Board with ad hoc assistance from two or more external experts in the field. All activity planners, authors, and reviewers are required to submit conflict of interest forms. These forms accompany the activity through the peer review process. Any reviewers who have a conflict of interest are recused. When a reviewer is recused, other suitable reviewers with no self-reported conflicts of interests are selected to conduct the reviews. Editors’ disclosures are published annually online, whereas reviewers’ disclosures are held in confidence within the Editorial Office. All final publication decisions are made by the Editorial Board. The acceptance of a manuscript is based on its originality and importance to the field as assessed by the Editors.

Credentials: Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Dafydd Thomas, M.D., Ph.D.

Credentials: Research Scientist, Department of Pathology, Division of General Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

David R. Lucas, M.D.

Credentials: Professor, Department of Pathology, Division of General Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

J. Sybil Biermann, M.D.

Credentials: Associate Professor, Department of Orthopedic Surgery, and Director, Musculoskeletal Oncology, Division of General Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Scott M. Schuetze, M.D., Ph.D.

Credentials: Associate Professor, Department of Medicine, Division of General Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Anita L. Hart, M.D.

Credentials: Department of Medicine, Division of General Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Rashmi Chugh, M.D.

Credentials: Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author has indicated no relevant commercial relationships.

Laurence H. Baker, D.O.

Credentials: Professor, Department of Internal Medicine, and Associate Chief, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Disclosures: The author is an advisory board member of Ascenta Therapeutics, Inc., The Hope Foundation, NCCN Guidelines Committee, and SARC (Sarcoma Alliance for Research through Collaboration), for which he receives no compensation.

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