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All Courses > Breast Cancer > 2008 > The CYP19 TTTA Repeat Polymorphism Is Related to the Prognosis of Premenopausal Stage I—II and Operable Stage III Breast Cancers

The CYP19 TTTA Repeat Polymorphism Is Related to the Prognosis of Premenopausal Stage I—II and Operable Stage III Breast Cancers

CME Activity Information
Release Date:
Date Credit Expires:
Time to Complete: 1 hour
Medium: Internet Online
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Instructions for Participation

  1. Read the following information before beginning the educational activity and click the "Take this course" link at the bottom of the page
  2. Study the educational activity
  3. Complete the CME quiz and evaluation
  4. After successful completion of the CME quiz and evaluation, you will receive the credit or participation certificate

*The CME quiz and evaluation must be completed by  in order to receive the credit or participation certificate.

Target Audience:

Learning Objectives

After completing this course, the reader should be able to:
  1. Describe why premenopausal women with the long allele of the CYP19 TTTA repeat polymorphism have a greater survival rate and may not gain benefit from adjuvant chemotherapy.
  2. Assess whether we need to revisit the routine use of adjuvant chemotherapy in high-risk premenopausal patients with the long allele of the CYP19 polymorphism.
  3. Explain why further validation in a randomized study with a large sample size is needed to determine whether the CYP19 TTTA repeat polymorphism can serve as a predictor in hormone receptor—positive premenopausal patients.

Accreditation and Credit Designation

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the School of Medicine of The University of North Carolina at Chapel Hill and The Oncologist. The School of Medicine of The University of North Carolina at Chapel Hill is accredited by the ACCME to provide continuing medical education for physicians.

The School of Medicine of The University of North Carolina at Chapel Hill designates this educational activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Policy

In compliance with the ACCME Standards of Commercial Support, it is the policy of the School of Medicine of The University of North Carolina at Chapel Hill to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities and to include information free of commercial bias and based on the best evidence available. All individuals in a position to influence the content of this activity have disclosed relevant financial interests or relationships of their own, their spouse/partner, or their worksite, with manufacturers or providers of commercial products, services, technology, or programs; and disclosed relationships with current non-governmental supporters of the activity.

All information is submitted and reviewed and found to be scientifically rigorous, based on the best available evidence, fair and balanced, and free of commercial bias. All the recommendations involving clinical medicine in this CME activity are based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME in support or justification of a patient care recommendation conforms to the generally accepted standards of experimental design, data collection and analysis.

Any potential conflicts of interests are resolved via The Oncologist's anonymous peer review process. All manuscripts are reviewed by the Editorial Board with ad hoc assistance from external experts in the field. All final publication decisions are made by the Editorial Board. The acceptance of a manuscript is based on its originality and importance to the field as assessed by the Editors.

Author Disclosure(s)

Section Editors Disclosures

CME Activity Director Disclosure

Frank M. Balis, M.D., CME Activity Director, Clinical Director, National Cancer Institute, has disclosed no financial relationships relevant to the content of this article.

Independent Peer Reviewers and Staff Managers Disclosures

No financial relationships relevant to the content of this article have been disclosed by the independent peer reviewers or staff managers.

Commercial Support

Non-governmental supporters of this activity: Merck and sanofi-aventis

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